cytotec_man's Journal

How to buy cheap Cytotec safely?

Pharmacological action of generic cytotec:

Buy synthetic analogue of prostaglandin E1. Has tsitoprotektornoe effect associated with increased formation of mucus in the stomach and increase bicarbonate secretion of gastric mucosa. Exerting a direct effect on parietal cells of the stomach, misoprostol inhibits basal, nocturnal and stimulated (food, histamine, pentagastrin) secretion. Reduces the basal (but not stimulated by histamine) produce pepsin.

Induces smooth muscle contraction of the myometrium and expands the cervix. Increases the frequency and force of contraction of the myometrium, providing a weak stimulating effect on smooth muscles of the digestive tract.

The action begins in 30 minutes and lasts at least 3-6 hours at a dose 50 mcg effects are mild and short, 200 mg - expressed.

Pharmacokinetics

When taken orally is rapidly and completely absorbed (food delays the absorption). Plasma protein binding is 85%. In the walls of the gastrointestinal tract and liver metabolized to pharmacologically active misoprostol acid. Cmax achieved within 12 min. Css - after 2 days. Not accumulates with repeated admission. T1 / 2 - 20-40 min. Excreted by the kidneys (80%) and bile (15%). If the kidney function may increase the Cmax of almost 2-fold and increased T1 / 2.

Dosage

Is the inside. Single dose - 200-400 mg, with high sensitivity and renal failure - 100 mcg. Multiplicity admission and duration of use depends on the indications and effectiveness of treatment.

Drug Interactions

In an application with antacids, the concentration of misoprostol in plasma.

In an application with magnesium-containing antacids may increase diarrhea.

In an application with atsenokumarolom described the case to reduce the anticoagulant action atsenokumarola.

In an application with diclofenac, indomethacin enhanced the side effects of diclofenac and indomethacin.
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Pregnancy and lactation

Contraindicated for use during pregnancy and lactation (breastfeeding).

Please be aware that misoprostol increases the tone of the uterus and can cause miscarriage in applying it as a gastroprotective funds.

If necessary, use among women of childbearing age should carry out pre-serum pregnancy test, which should remain negative in the 2 weeks before treatment with cheap misoprostol. Treatment can be started only on 2-3rd day of normal menses. During the whole course of treatment should use reliable methods of contraception.